Protein Details: Potassium voltage-gated channel subfamily H member 3

Protein ID

ICDB_Pro_1704

Protein Name

Potassium voltage-gated channel subfamily H member 3

Gene Name

Kcnh3; Elk2

Organism

Mus musculus (Mouse)

Length

1095 amino acids

AlphaFoldDB

AF-Q9WVJ0-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly

Sequence

MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDNWKERGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQGHTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRSLDGLQLPPMPWNVPPDLSPRVVDGIEDGCSSDQPKFSFRVGQSGPECSSSPSPGTESGLLTVPLGPSEARNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLILVPQGEGQCPRGSGEEPCPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGQPPPLMAPWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPSEEGARTGTPAPVSQAEATSTGEPPPGPGGRALPWDPHSLEMVLIGCHGPGTVQWTQEEGTGV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

593..708

Disease

Location

Detected in brain; but not in other tissues.

DOI ID

10.1523/jneurosci.19-08-02906.1999; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504

RefSeq

NP_034731.3

Feature